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Treat Your Acne Head-On: Those dealing with unforgiving, stubborn acne despite following the advice above should also take the spot-treatment approach. Dr. Zeichner recommends a product that contains benzoyl peroxide – such as Neutrogena On the Spot Acne Treatment, $9 – which “helps lower levels of acne–causing bacteria to reduce inflammation of the skin.” We also like  Hero Cosmetics Micropoint for Blemishes, $13.